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1.
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9 p, 1.0 MB |
Rotigotine transdermal patch and sleep in Parkinson's disease : where are we now?
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Rosa-Grilo, Miguel (King's College London) ;
Qamar, Mubasher A. (King's College London) ;
Taddei, Raquel N. (King's College London) ;
Pagonabarraga Mora, Javier (Institut d'Investigació Biomèdica Sant Pau) ;
Kulisevsky, Jaime (Institut d'Investigació Biomèdica Sant Pau) ;
Sauerbier, Anna (King's College London) ;
Chaudhuri, K.Ray (King's College London) ;
Universitat Autònoma de Barcelona
A wide range of sleep dysfunction complicates Parkinson's disease during its course from prodromal to palliative stage. It is now increasingly acknowledged that sleep disturbances are thus integral to the disease and pose a significant burden impacting on quality of life of patients. [...]
2017 -  10.1038/S41531-017-0030-4
NPJ Parkinson's disease, Vol. 3 Núm. 1 (2017) , p. 28
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2.
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9 p, 1.0 MB |
Safinamide in the treatment pathway of Parkinson's Disease : a European Delphi Consensus
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Stocchi, Fabrizio (University and IRCCS San Raffaele Pisana) ;
Antonini, Angelo (University of Padua) ;
Berg, Daniela (Hertie-Institute of Clinical Brain Research Tübingen) ;
Bergmans, Bruno (Ghent University Hospital. (Bèlgica)) ;
Jost, Wolfgang (Parkinson-Klinik Ortenau) ;
Katzenschlager, Regina (Neurodegenerative Disorders Klinik Donaustadt) ;
Kulisevsky, Jaime (Institut d'Investigació Biomèdica Sant Pau) ;
Odin, Per (Lund University) ;
Valldeoriola, Francesc (Hospital Clínic i Provincial de Barcelona) ;
Ray Chaudhuri, K. (King's College Hospital NHS Foundation Trust) ;
Universitat Autònoma de Barcelona
Safinamide is a highly selective, reversible MAO B-inhibitor recently marketed in European and North American countries. To better define clinical indications regarding motor and non-motor symptoms, targeted population and safety of this compound, ten movement disorders specialists, experts in their field, convened and developed a panel of statements on: the role of glutamate in Parkinson's disease, introduction to fluctuations, efficacy of safinamide on motor symptoms, motor complications and non-motor symptoms, quality of life, safety of safinamide and target population for use. [...]
2022 - 10.1038/s41531-022-00277-z
NPJ Parkinson's disease, Vol. 8 (february 2022)
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3.
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15 p, 2.7 MB |
Lysosomal lipid alterations caused by glucocerebrosidase deficiency promote lysosomal dysfunction, chaperone-mediated-autophagy deficiency, and alpha-synuclein pathology
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Navarro, Alba (Hospital Universitari Vall d'Hebron. Institut de Recerca) ;
Fernández González, Irene (Hospital Universitari Vall d'Hebron. Institut de Recerca) ;
Riera del Brio, Jordi (Hospital Universitari Vall d'Hebron. Institut de Recerca) ;
Montpeyó Garcia-Moreno, Marta (Hospital Universitari Vall d'Hebron. Institut de Recerca) ;
Albert-Bayo, Mercé (Hospital Universitari Vall d'Hebron. Institut de Recerca) ;
Lopez-Royo, Tresa (Hospital Universitari Vall d'Hebron. Institut de Recerca) ;
Castillo-Sanchez, Pablo (Hospital Universitari Vall d'Hebron. Institut de Recerca) ;
Carnicer-Cáceres, Clara (Institució Catalana de Recerca i Estudis Avançats) ;
Arranz-Amo, Jose Antonio (Hospital Universitari Vall d'Hebron. Institut de Recerca) ;
Castillo-Ribelles, Laura (Hospital Universitari Vall d'Hebron. Institut de Recerca) ;
Pradas-Gracia, Eddie (Hospital Universitari Vall d'Hebron. Institut de Recerca) ;
Casas, Josefina (Institut de Química Avançada de Catalunya) ;
Vila Bover, Miquel (Hospital Universitari Vall d'Hebron. Institut de Recerca) ;
Martinez-Vicente, Marta (Hospital Universitari Vall d'Hebron. Institut de Recerca) ;
Universitat Autònoma de Barcelona
Mutations in the GBA gene that encodes the lysosomal enzyme β-glucocerebrosidase (GCase) are a major genetic risk factor for Parkinson's disease (PD). In this study, we generated a set of differentiated and stable human dopaminergic cell lines that express the two most prevalent GBA mutations as well as GBA knockout cell lines as a in vitro disease modeling system to study the relationship between mutant GBA and the abnormal accumulation of α-synuclein. [...]
2022 - 10.1038/s41531-022-00397-6
NPJ Parkinson's disease, Vol. 8 (october 2022)
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4.
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7 p, 823.4 KB |
Non-motor predictors of 36-month quality of life after subthalamic stimulation in Parkinson disease
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Jost, Stefanie Theresa (University of Cologne. Faculty of Medicine and University Hospital Cologne. Department of Neurology) ;
Visser-Vandewalle, Veerle (University of Cologne. Faculty of Medicine and University Hospital Cologne. Department of Stereotaxy and Functional Neurosurgery) ;
Rizos, Alexandra Marianne (King's College London. Parkinson Foundation International Centre of Excellence) ;
Loehrer, Philipp Alexander (Department of Neurology. University Hospital Giessen and Marburg. Campus Marburg) ;
Silverdale, Monty (Department of Neurology and Neurosurgery. Salford Royal NHS Foundation Trust. Manchester Academic Health Science Centre. University of Manchester) ;
Evans, Julian (Department of Neurology and Neurosurgery. Salford Royal NHS Foundation Trust. Manchester Academic Health Science Centre. University of Manchester) ;
Samuel, Michael (King's College London. Parkinson Foundation International Centre of Excellence) ;
Petry-Schmelzer, Jan Niklas (University of Cologne. Faculty of Medicine and University Hospital Cologne. Department of Neurology) ;
Sauerbier, Anna (Institute of Psychiatry. Psychology and Neuroscience. King's College London) ;
Gronostay, Alexandra (University of Cologne. Faculty of Medicine and University Hospital Cologne. Department of Neurology) ;
Barbe, Michael T. (University of Cologne. Faculty of Medicine and University Hospital Cologne. Department of Neurology) ;
Fink, Gereon R. (Cognitive Neuroscience. Institute of Neuroscience and Medicine (INM-3). Research Centre Jülich) ;
Ashkan, Keyoumars (King's College London. Parkinson Foundation International Centre of Excellence) ;
Antonini, Angelo (Padova University. Department of Neurosciences (DNS)) ;
Martinez-Martin, Pablo (Centro de Investigación Biomédica en Red sobre Enfermedades Neurodegenerativas) ;
Chaudhuri, Kallol Ray (King's College London. Institute of Psychiatry, Psychology & Neuroscience) ;
Timmermann, Lars (University Hospital Giessen and Marburg) ;
Dafsari, Haidar S. (University of Cologne. Faculty of Medicine and University Hospital Cologne. Department of Neurology) ;
Bhidayasiri, Roongroj (Chulalongkorn Centre of Excellence for Parkinson's Disease & Related Disorders. Department of Medicine. Faculty of Medicine. Chulalongkorn University and King Chulalongkorn Memorial Hospital. Thai Red Cross Society) ;
Falup-Pecurariu, Cristian (Faculty of Medicine. Transilvania University of Brașov) ;
Jeon, Beomseok (Department of Neurology. Seoul National University College of Medicine) ;
Leta, Valentina (King's College London. Institute of Psychiatry. Psychology & Neuroscience) ;
Borghammer, Per (Aarhus University Hospital (Aarhus, Dinamarca)) ;
Odin, Per (University of Lund. Faculty of Medicine) ;
Schrag, Anette (UCL Institute of Neurology (Regne Unit)) ;
Storch, Alexander (German Center for Neurodegenerative Diseases (DZNE). Research Site Dresden) ;
Rodríguez-Violante, Mayela (Movement Disorders Clinic. National Institute of Neurology and Neurosurgery) ;
Weintraub, Daniel (Parkinson's Disease and Mental Illness Research. Education and Clinical Centers. Philadelphia Veterans Affairs Medical Center) ;
Adler, Charles (The Parkinson's Disease and Movement Disorders Center. Department of Neurology. Mayo Clinic) ;
Barone, Paolo (Center for Neurodegenerative Diseases (CEMAND). Neuroscience Section. University of Salerno) ;
Brooks, David J. (Department of Nuclear Medicine and PET Centre. Aarhus University Hospital) ;
Brown, Richard (Department of Medicine. University of Birmingham Institute of Cardiovascular Sciences. City Hospital) ;
Cantillon, Marc (Reviva Pharmaceuticals. Inc) ;
Carroll, Camille (Faculty of Medicine and Dentistry. University of Plymouth) ;
Coelho, Miguel (FAS Center for Systems Biology. Harvard University) ;
Henriksen, Tove (Movement Disorder Clinic. University Hospital of Bispebjerg) ;
Hu, Michele (Nuffield Department of Clinical Neurosciences. University of Oxford) ;
Jenner, Peter (Neurodegenerative Diseases Research Group. Institute of Pharmaceutical Sciences. Faculty of Life Sciences and Medicine. King's College London) ;
Kramberger, Milica (Department of Neurology. University Medical Centre Ljubljana) ;
Kumar, Padma (Parkinson's Disease Service for the Older Person. Rankin Park Centre. John Hunter Hospital. HNELHD) ;
Kurtis, Monica M. (Functional Movement Disorders Unit. Movement Disorders Program. Neurology Department. Hospital Ruber Internacional) ;
Lewis, Simon (Brain and Mind Centre. University of Sydney) ;
Litvan, Irene (Department of Neurosciences Movement Disorders Center. University of California) ;
Lyons, Kelly (University of Kansas Medical Center) ;
Martino, Davide (Department of Clinical Neurosciences. University of Calgary & Hotchkiss Brain Institute) ;
Masellis, Mario (Hurvitz Brain Sciences Program. Sunnybrook Research Institute) ;
Mochizuki, Hideki (Department of Neurology. Osaka University Graduate School of Medicine) ;
Morley, James F. (Department of Neurology. University of Pennsylvania) ;
Nirenberg, Melissa (Department of Neurology. NYU School of Medicine) ;
Pagonabarraga Mora, Javier (Institut d'Investigació Biomèdica Sant Pau) ;
Panicker, Jalesh (Neurology. National Hospital for Neurology & Neurosurgery) ;
Pavese, Nicola (Newcastle Magnetic Resonance Centre & Positron Emission Tomography Centre. Newcastle University. Campus for Ageing & Vitality) ;
Pekkonen, Eero (Department of Neurology. Helsinki University Hospital. and Department of Neurological Sciences (Neurology). University of Helsinki) ;
Postuma, Ron (Research Institute of McGill University Health Centre) ;
Rosales, Raimon L. (Center for Neurodiagnostic and Therapeutic Services. Metropolitan Medical Center) ;
Schapira, Anthony (Department of Clinical Neurosciences. University College London (UCL) Institute of Neurology. Royal Free Campus. Rowland Hill Street) ;
Simuni, Tanya (Department of Neurology. Northwestern University. Feinberg School of Medicine) ;
Stocchi, Fabrizio (University and Institute for Research and Medical Care. IRCCS San Raffaele) ;
Subramanian, Indu (UCLA/West LA VA) ;
Tagliati, Michele (Cedars-Sinai Medical Center) ;
Tinazzi, Michele (Department of Neuroscience. Biomedicine. and Movement. University of Verona) ;
Toledo, Jon (Department of Neurology. Houston Methodist Hospital) ;
Tsuboi, Yoshio (Department of Neurology. Fukuoka University) ;
Walker, Richard (Northumbria Healthcare NHS Foundation Trust. North Tyneside General Hospital. Rake Lane)
To identify predictors of 36-month follow-up quality of life (QoL) outcome after bilateral subthalamic nucleus deep brain stimulation (STN-DBS) in Parkinson's disease (PD). In this ongoing, prospective, multicenter international study (Cologne, Manchester, London) including 73 patients undergoing STN-DBS, we assessed the following scales preoperatively and at 6-month and 36-month follow-up: PD Questionnaire-8 (PDQ-8), NMSScale (NMSS), Scales for Outcomes in PD (SCOPA)-motor examination, -activities of daily living, and -complications, and levodopa equivalent daily dose (LEDD). [...]
2021 - 10.1038/s41531-021-00174-x
NPJ Parkinson's disease, Vol. 7 Núm. 1 (december 2021) , p. 48
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5.
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10 p, 1.1 MB |
Predictors of clinically significant quality of life impairment in Parkinson's disease
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Santos García, Diego (Complejo Hospitalario Universitario de A Coruña) ;
de Deus Fonticoba, Teresa (Complejo Hospitalario Universitario de Ferrol) ;
Cores Bartolomé, Carlos (Complejo Hospitalario Universitario de A Coruña) ;
Muñoz, Guillermo (Complejo Hospitalario Universitario de A Coruña) ;
Paz González, José M. (Complejo Hospitalario Universitario de A Coruña) ;
Martínez Miró, Cristina (Complejo Hospitalario Universitario de A Coruña) ;
Suárez, Ester (Complejo Hospitalario Universitario de Ferrol) ;
Jesús, Silvia (Centro de Investigación Biomédica en Red sobre Enfermedades Neurodegenerativas) ;
Aguilar Barberà, Miquel (Hospital Universitari MútuaTerrassa (Terrassa, Catalunya)) ;
Pastor, Pau (Hospital Universitari MútuaTerrassa (Terrassa, Catalunya)) ;
Planellas, Lluis (Neurología. Clínica del Pilar) ;
Cosgaya, Marina (Hospital Clínic i Provincial de Barcelona) ;
García Caldentey, Juan (Centro Neurológico Oms 42) ;
Caballol, Nuria (Hospital de Sant Joan Despí Moisès Broggi) ;
Legarda, Inés (Hospital Universitari Son Espases (Palma de Mallorca, Balears)) ;
Hernández-Vara, Jorge (Hospital Universitari Vall d'Hebron) ;
Cabo-Lopez, Iria (Complejo Hospitalario Universitario de Pontevedra) ;
López Manzanares, Luis (Hospital Universitario de la Princesa (Madrid)) ;
González Aramburu, Isabel (Hospital Universitario Marqués de Valdecilla (Santander, Cantabria)) ;
Ávila, Asunción (Consorci Sanitari Integral. Hospital General de L'Hospitalet. L'Hospitalet de Llobregat) ;
Catalán, Maria J. (Hospital Universitario Clínico San Carlos (Madrid)) ;
Nogueira, Víctor (Hospital Da Costa) ;
Puente, Víctor (Hospital del Mar (Barcelona, Catalunya)) ;
Ruíz de Arcos, María (Hospital Universitario Virgen Macarena (Sevilla, Andalusia)) ;
Borrué, Carmen (Hospital Universitario Infanta Sofía (San Sebastián de los Reyes)) ;
Solano Vila, Berta (Institut Català de la Salut) ;
Álvarez Sauco, María (Hospital General Universitario de Elche) ;
Vela, Lydia (Hospital Universitario Fundación Alcorcón) ;
Escalante, Sonia (Hospital de Tortosa Verge de la Cinta) ;
Cubo, Esther (Complejo Asistencial Universitario de Burgos) ;
Carrillo Padilla, Francisco (Hospital Universitario de Canarias (La Laguna)) ;
Martínez-Castrillo, Juan Carlos (Hospital Universitario Ramón y Cajal (Madrid)) ;
Sánchez Alonso, Pilar (Hospital Universitario Puerta de Hierro Majadahonda (Madrid)) ;
Alonso Losada, Maria G. (Hospital Álvaro Cunqueiro (Vigo)) ;
López Ariztegui, Nuria (Complejo Hospitalario de Toledo) ;
Gastón, Itziar (Complejo Hospitalario de Navarra) ;
Clavero, Pedro (Complejo Hospitalario de Navarra) ;
Kulisevsky, Jaime (Institut d'Investigació Biomèdica Sant Pau) ;
Blázquez Estrada, Marta (Hospital Universitario Central de Asturias) ;
Seijo, Manuel (Complejo Hospitalario Universitario de Pontevedra) ;
Rúiz Martínez, Javier (Hospital Universitario de Donostia (Sant Sebastià, País Basc)) ;
Valero, Caridad (Hospital Arnau de Vilanova (València)) ;
Kurtis, Mónica (Hospital Ruber Internacional) ;
Fàbregues-Boixar i Nebot, Oriol de (Hospital Universitari Vall d'Hebron) ;
González-Ardura, Jessica (Hospital Universitario de Cabueñes (Gijón)) ;
Ordás, Carlos (Hospital Universitario Rey Juan Carlos (Madrid)) ;
López Díaz, Luis M. (Complejo Hospitalario Universitario de Ourense) ;
McAfee, Darrian (Univeristy of Pennsylvania) ;
Martinez-Martin, Pablo (Centro de Investigación Biomédica en Red sobre Enfermedades Neurodegenerativas) ;
Mir, Pablo (Centro de Investigación Biomédica en Red sobre Enfermedades Neurodegenerativas) ;
Adarmes-Gómez, A.D (Hospital Universitario Virgen del Rocío (Sevilla, Andalusia)) ;
Almeria, Marta (Mútua de Terrassa) ;
Alonso-Cánovas, Araceli (Hospital Universitario Ramón y Cajal (Madrid)) ;
Alonso Frech, Fernando (Hospital Universitario Clínico San Carlos (Madrid)) ;
Alonso Redondo, Rubén (Hospital Universitario Lucus Augusti (Lugo)) ;
Álvarez, Ignacio (Hospital Universitari MútuaTerrassa (Terrassa, Catalunya)) ;
Aneiros Díaz, Ángel (Complejo Hospitalario Universitario de Ferrol) ;
Arnáiz, Sandra (Complejo Asistencial Universitario de Burgos) ;
Arribas, Sonia (Mútua de Terrassa) ;
Ascunce Vidondo, Arancha (Complejo Hospitalario de Navarra) ;
Bernardo Lambrich, Noemí (Hospital de Tortosa Verge de la Cinta) ;
Bejr-kasem, Helena (Institut d'Investigació Biomèdica Sant Pau) ;
Botí, M (Mútua de Terrassa) ;
Buongiorno, María Teresa (Mútua de Terrassa) ;
Cabello González, Carolina (Complejo Hospitalario de Navarra) ;
Cámara, Ana (Hospital Clínic i Provincial de Barcelona) ;
Canfield Medina, H (Complejo Hospitalario Universitario de Ferrol) ;
Carrillo, Fátima (Instituto de Biomedicina de Sevilla) ;
Casas, Elena (Complejo Asistencial Universitario de Burgos) ;
Cortina Fernández, Ana (Complejo Hospitalario Universitario de Ferrol) ;
Cots-Foraster, Anna (Institut Català de la Salut) ;
Crespo Cuevas, Ane Miren (Hospital del Mar (Barcelona, Catalunya)) ;
Díez-Fairen, Mónica (Hospital Universitari MútuaTerrassa (Terrassa, Catalunya)) ;
Dotor García-Soto, Julio (Hospital Universitario Virgen Macarena (Sevilla, Andalusia)) ;
Erro, Elena (Complejo Hospitalario de Navarra) ;
Estelrich Peyret, Elena (Institut Català de la Salut) ;
Fernández Guillán, Noelia (Complejo Hospitalario Universitario de Ferrol) ;
Gámez, Pedro (Complejo Asistencial Universitario de Burgos) ;
Gallego, Miguel (Hospital Universitario de la Princesa (Madrid)) ;
García Campos, Cristina (Hospital Universitario Virgen Macarena (Sevilla, Andalusia)) ;
García Moreno, José Manuel (Hospital Universitario Virgen Macarena (Sevilla, Andalusia)) ;
Gómez Garre, Maria P. (Hospital Universitario Virgen del Rocío (Sevilla, Andalusia)) ;
Gómez Mayordomo, Víctor (Hospital Clínico San Carlos (Madrid)) ;
González Aloy, Javier (Institut Català de la Salut) ;
González García, Beatriz (Hospital Universitario de la Princesa (Madrid)) ;
González Palmás, Maria J. (Complejo Hospitalario Universitario de Pontevedra) ;
González Toledo, G.R (Hospital Universitario de Canarias (La Laguna)) ;
Gabriel, R. (Hospital Universitario de Canarias (La Laguna)) ;
Golpe Díaz, Ana (Complejo Hospitalario Universitario de Ferrol) ;
Grau Solá, Mireia (Hospital de Sant Joan Despí Moisès Broggi) ;
Guardia, Gemma (Hospital Universitari MútuaTerrassa (Terrassa, Catalunya)) ;
Horta, Andrea (Institut d'Investigació Biomèdica Sant Pau) ;
Idoate Calderón, Daniel (Complejo Hospitalario Universitario de Pontevedra) ;
Infante, Jon (Hospital Universitario Marqués de Valdecilla (Santander, Cantabria)) ;
Labandeira, Carmen (Hospital Álvaro Cunqueiro (Vigo)) ;
Labrador-Espinosa, Miguel A (Instituto de Biomedicina de Sevilla) ;
Lacruz, Francisco (Complejo Hospitalario de Navarra) ;
Lage Castro, Melva (Complejo Hospitalario Universitario de Pontevedra) ;
Lastres Gómez, Sonia (Complejo Hospitalario Universitario de Pontevedra) ;
López Seoane, Balbino (Hospital General Juan Cardona) ;
Lucas del Pozo, Sara (Hospital Universitari Son Espases (Palma de Mallorca, Balears)) ;
Macías, Yolanda (Hospital Universitario Fundación Alcorcón) ;
Mata, Marina (Hospital Universitario Infanta Sofía (San Sebastián de los Reyes)) ;
Martí Andres, Gloria (Clínica Universidad de Navarra) ;
Martí, Maria J. (Hospital Clínic i Provincial de Barcelona) ;
Meitín, Maria T. (Hospital Da Costa) ;
Menéndez González, Manuel (Hospital Universitario Central de Asturias) ;
Méndez del Barrio, Carlota (Hospital Universitario Virgen del Rocío (Sevilla, Andalusia)) ;
Miranda Santiago, Javier (Complejo Asistencial Universitario de Burgos) ;
Morales Casado (COPPADIS Study Group) ;
María, I. (Complejo Hospitalario de Toledo) ;
Moreno Diéguez, Antonio (Complejo Hospitalario Universitario de Ferrol) ;
Novo Amado, Alba (Hospital General Juan Cardona) ;
Novo Ponte, Sabela (Hospital Universitario Puerta de Hierro Majadahonda (Madrid)) ;
Pagonabarraga Mora, Javier (Institut d'Investigació Biomèdica Sant Pau) ;
Pareés, Isabel (Hospital Ruber Internacional) ;
Pascual-Sedano, Berta María (Institut d'Investigació Biomèdica Sant Pau) ;
Pérez Fuertes, Aída (Complejo Hospitalario Universitario de Ferrol) ;
Pérez Noguera, Rafael (Hospital Universitario Virgen Macarena (Sevilla, Andalusia)) ;
Planas-Ballvé, Ana (Hospital de Sant Joan Despí Moisès Broggi) ;
Prats, Marian A. (Institut Català de la Salut) ;
Prieto Jurczynska, Cristina (Hospital Universitario Rey Juan Carlos (Madrid)) ;
Pueyo Morlans, Mercedes (Hospital Universitario de Canarias (La Laguna)) ;
Puig-Davi, Arnau (Institut d'Investigació Biomèdica Sant Pau) ;
Redondo Rafales, Nuria (Hospital Universitario de la Princesa (Madrid)) ;
Rodríguez Méndez, Luisa (Complejo Hospitalario Universitario de Ferrol) ;
Rodríguez Pérez, Amparo B. (Hospital General Universitario de Elche) ;
Roldán, Florinda (Hospital Universitario Virgen del Rocío (Sevilla, Andalusia)) ;
Sánchez-Carpintero, Macarena (Complejo Hospitalario Universitario de Ferrol) ;
Sánchez Díez, Gemma (Hospital Universitario Ramón y Cajal (Madrid)) ;
Sánchez Rodríguez, Antonio (Hospital Universitario Marqués de Valdecilla (Santander, Cantabria)) ;
Santacruz, Pilar (Hospital Clínic i Provincial de Barcelona) ;
Segundo Rodríguez, José C. (Complejo Hospitalario de Toledo) ;
Sierra Peña, María (Hospital Universitario Marqués de Valdecilla (Santander, Cantabria)) ;
Tartari, Juan P. (Mutua de Terrassa) ;
Vargas, Laura (Hospital Universitario Virgen del Rocío (Sevilla, Andalusia)) ;
Villanueva, Clara (Hospital Universitario Clínico San Carlos (Madrid)) ;
Vives-Pastor, Bárbara (Hospital Universitari Son Espases (Palma de Mallorca, Balears)) ;
Villar, María D. (Hospital Universitario de Canarias (La Laguna))
Quality of life (QOL) plays an important role in independent living in Parkinson's disease (PD) patients, being crucial to know what factors impact QoL throughout the course of the disease. Here we identified predictors of QoL impairment in PD patients from a Spanish cohort. [...]
2021 - 10.1038/s41531-021-00256-w
NPJ Parkinson's disease, Vol. 7 Núm. 1 (december 2021) , p. 118
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16 p, 569.4 KB |
Staging Parkinson's Disease Combining Motor and Nonmotor Symptoms Correlates with Disability and Quality of Life
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Santos García, Diego (Complejo Hospitalario Universitario de A Coruña) ;
de Deus Fonticoba, Teresa (Complejo Hospitalario Universitario de Ferrol) ;
Paz González, José M. (Complejo Hospitalario Universitario de A Coruña) ;
Cores Bartolomé, Carlos (Complejo Hospitalario Universitario de A Coruña) ;
Valdés Aymerich, Lorena (Complejo Hospitalario Universitario de A Coruña) ;
Muñoz Enríquez, J. G. (Complejo Hospitalario Universitario de A Coruña) ;
Suárez Castro, Ester (Complejo Hospitalario Universitario de Ferrol) ;
Jesús, Silvia (Centro de Investigación Biomédica en Red sobre Enfermedades Neurodegenerativas) ;
Aguilar Barberà, Miquel (Hospital Universitari MútuaTerrassa (Terrassa, Catalunya)) ;
Pastor, Pau (Hospital Universitari MútuaTerrassa (Terrassa, Catalunya)) ;
Planellas, Lluis (Hospital Clínic i Provincial de Barcelona) ;
Cosgaya, Marina (Hospital Clínic i Provincial de Barcelona) ;
García Caldentey, Juan (Centro Neurológico Oms 42, Palma de Mallorca) ;
Caballol, Nuria (Hospital de Sant Joan Despí Moisès Broggi) ;
Legarda, Inés (Hospital Universitari Son Espases (Palma de Mallorca, Balears)) ;
Hernández-Vara, Jorge (Hospital Universitari Vall d'Hebron) ;
Cabo-Lopez, Iria (Complejo Hospitalario Universitario de Pontevedra) ;
López Manzanares, Lydia (Hospital Universitario de la Princesa (Madrid)) ;
Gonzalez-Aramburu, Isabel (Hospital Universitario Marqués de Valdecilla (Santander, Cantabria)) ;
Ávila, Asunción (Hospital General de l'Hospitalet) ;
Catalán, María José (Hospital Clínico San Carlos (Madrid)) ;
Nogueira, Víctor (Hospital Da Costa, Burela, Lugo) ;
Puente, Víctor (Hospital del Mar (Barcelona, Catalunya)) ;
García Moreno, José Manuel (Hospital Universitario Virgen Macarena (Sevilla, Andalusia)) ;
Borrué, Carmen (Hospital Universitario Infanta Sofía (San Sebastián de los Reyes)) ;
Solano Vila, Berta (Institut Català de la Salut. Direcció d'Atenció Primària (Girona, Catalunya)) ;
Álvarez Sauco, María (Hospital General Universitario de Elche) ;
Vela, Lydia (Hospital Universitario Fundación Alcorcón) ;
Escalante, Sonia (Hospital de Tortosa Verge de la Cinta) ;
Cubo, Esther (Complejo Asistencial Universitario de Burgos) ;
Carrillo Padilla, Francisco (Hospital Universitario de Canarias (La Laguna)) ;
Martínez-Castrillo, Juan Carlos (Hospital Universitario Ramón y Cajal (Madrid)) ;
Sánchez Alonso, Pilar (Hospital Universitario Puerta de Hierro Majadahonda (Madrid)) ;
Alonso Losada, Maria G. (Hospital Álvaro Cunqueiro (Vigo)) ;
López Ariztegui, Nuria (Complejo Hospitalario de Toledo) ;
Gastón, Itziar (Complejo Hospitalario de Navarra) ;
Kulisevsky, Jaime (Institut d'Investigació Biomèdica Sant Pau) ;
Blázquez Estrada, Marta (Hospital Universitario Central de Asturias) ;
Seijo, Manuel (Complejo Hospitalario Universitario de Pontevedra) ;
Ruiz Martínez, Javier (Hospital Universitario de Donostia (Sant Sebastià, País Basc)) ;
Valero, Caridad (Hospital Arnau de Vilanova (Lleida, Catalunya)) ;
Kurtis, Mónica (Hospital Ruber Internacional, Madrid) ;
Fàbregues-Boixar i Nebot, Oriol de (Hospital Universitari Vall d'Hebron) ;
González-Ardura, Jessica (Hospital Universitario Lucus Augusti (Lugo)) ;
Ordás, Carlos (Hospital Universitario Rey Juan Carlos (Madrid)) ;
López Díaz, Luis M. (Complejo Hospitalario Universitario de Ourense) ;
Mir, Pablo (Hospital Universitario Virgen del Rocío (Sevilla, Andalusia)) ;
Martinez-Martin, Pablo (Centro de Investigación Biomédica en Red sobre Enfermedades Neurodegenerativas) ;
COPPADIS Study Group, None (Fundación Curemos el Parkinson, C/Juana de Vega 23 2°, A Coruña 15004, Spain) ;
Universitat Autònoma de Barcelona
In a degenerative disorder such as Parkinson's disease (PD), it is important to establish clinical stages that allow to know the course of the disease. Our aim was to analyze whether a scale combining Hoehn and Yahr's motor stage (H&Y) and the nonmotor symptoms burden (NMSB) (assessed by the nonmotor symptoms scale (NMSS)) provides information about the disability and the patient's quality of life (QoL) with regard to a defined clinical stage. [...]
2021 - 10.1155/2021/8871549
Parkinson's Disease, Vol. 2021 (may 2021)
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5 p, 1.5 MB |
Tremor Types in Parkinson Disease : A Descriptive Study Using a New Classification
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Gironell, Alexandre (Institut d'Investigació Biomèdica Sant Pau) ;
Pascual-Sedano, Berta María (Institut d'Investigació Biomèdica Sant Pau) ;
Aracil-Bolaños, Ignacio (Institut d'Investigació Biomèdica Sant Pau) ;
Marín-Lahoz, Juan (Institut d'Investigació Biomèdica Sant Pau) ;
Pagonabarraga Mora, Javier (Institut d'Investigació Biomèdica Sant Pau) ;
Kulisevsky, Jaime (Institut d'Investigació Biomèdica Sant Pau) ;
Universitat Autònoma de Barcelona
The current classification of tremor types in Parkinson disease (PD) is potentially confusing, particularly for mixed tremor, and there is no label for pure resting tremor. With a view to better defining the clinical phenomenological classification of these tremors, our group relabeled the different types as follows: pure resting tremor (type I); mixed resting and action tremor with similar frequencies (type II) divided, according to action tremor presentation, into II-R when there is a time lag and II-C otherwise; pure action tremor (type III); and mixed resting and action tremor with differing frequencies (type IV). [...]
2018 - 10.1155/2018/4327597
Parkinson's Disease, Vol. 2018 (september 2018)
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8 p, 1.0 MB |
Serum metabolic biomarkers for synucleinopathy conversion in isolated REM sleep behavior disorder
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Laguna, Ariadna (Hospital Universitari Vall d'Hebron. Institut de Recerca) ;
Xicoy, Helena (Donders Institute for Brain) ;
Tolosa, Eduardo (Institut d'Investigacions Biomèdiques August Pi i Sunyer) ;
Serradell, Mònica (Hospital Clínic i Provincial de Barcelona) ;
Vilas, Dolores (Institut d'Investigacions Biomèdiques August Pi i Sunyer) ;
Gaig, Carles (Hospital Clínic i Provincial de Barcelona) ;
Fernández, Manel (Institut d'Investigacions Biomèdiques August Pi i Sunyer) ;
Yanes, Oscar (Universitat Rovira i Virgili) ;
Santamaria Cano, Joan (Hospital Clínic i Provincial de Barcelona) ;
Amigó, Núria (Biosfer Teslab, Reus) ;
Iranzo, Alex (Hospital Clínic i Provincial de Barcelona) ;
Vila Bover, Miquel (Institució Catalana de Recerca i Estudis Avançats) ;
Universitat Autònoma de Barcelona
Isolated rapid eye movement (REM) sleep behavior disorder (iRBD) is a prodromal stage of Lewy-type synucleinopathies (LTS), which can present either with an initial predominant parkinsonism (Parkinson's disease (PD)) or dementia (dementia with Lewy bodies (DLB)). [...]
2021 - 10.1038/s41531-021-00184-9
NPJ Parkinson's disease, Vol. 7 (may 2021)
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12 p, 501.8 KB |
A European Observational Study to Evaluate the Safety and the Effectiveness of Safinamide in Routine Clinical Practice : The SYNAPSES Trial
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Abbruzzese, Giovanni (University of Genoa) ;
Kulisevsky, Jaime (Institut d'Investigació Biomèdica Sant Pau) ;
Bergmans, Bruno (Universitair Ziekenhuis Gent) ;
Gomez-Esteban, Juan C. (Instituto de Investigación Sanitaria Biocruces Bizkaia) ;
Kägi, Georg (Cantonal Hospital St.Gallen) ;
Raw, Jason (Fairfield General Hospital) ;
Stefani, Alessandro (University Policlinico Tor Vergata) ;
Warnecke, Tobias (University of Muenster) ;
Jost, Wolfgang H. (University of Freiburg) ;
Universitat Autònoma de Barcelona
Safinamide modulates both dopaminergic and glutamatergic systems with positive effects on motor and non-motor symptoms of Parkinson's disease (PD). The drug utilization study SYNAPSES was designed to investigate the use of safinamide in routine clinical practice, as recommended by the European Medicines Agency. [...]
2021 - 10.3233/JPD-202224
Journal of Parkinson's Disease, Vol. 11 (february 2021) , p. 187-198
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